Mounjaro Dosage Chart: The Full Titration Schedule

Tirzepatide is titrated in a fixed sequence of dose strengths, typically held for about four weeks each before the next step, until you reach either the maximum dose or the lowest dose that is working well for you. The table below shows the standard sequence — your prescriber's actual schedule may move slower.

The 2.5 mg starting dose is not expected to produce much weight loss on its own — it exists to let your gut adapt to slower digestion before the dose that actually treats obesity. Moving to 5 mg is usually where people start noticing a real reduction in appetite. It is also common for mild nausea to reappear briefly after this step, which is expected and typically settles within a week or two.

Your doctor decides this, not a fixed calendar. The general pattern is a step up roughly every four weeks, but that is a default, not a rule. Two things routinely change it:

• Side effects — if a dose increase brings nausea or GI symptoms you cannot manage, your doctor may hold you at the current dose for longer before trying again.
• Response — if you are losing weight steadily and tolerating a middle dose well, staying there rather than pushing to the maximum is a legitimate outcome.

Never self-escalate the dose. Going up faster than your body adapts is the most common reason people stop the medicine altogether from nausea and vomiting.

The maximum approved dose is 15 mg weekly. In the SURMOUNT-1 trial, participants on the higher doses saw the largest average reductions in body weight, up to around 20.9% at 72 weeks. That does not mean everyone needs to reach 15 mg — many people reach their goals at a lower maintenance dose, and your doctor weighs your results against your tolerance rather than defaulting to the ceiling.

Semaglutide (Ozempic/Wegovy) follows the same logic — a low starting dose, held for about four weeks, then stepped up — but with different numbers. Wegovy's schedule runs 0.25 → 0.5 → 1.0 → 1.7 → 2.4 mg; see Wegovy in India for that full chart. Tirzepatide (Mounjaro) and semaglutide are not interchangeable dose-for-dose — they are different molecules with independent titration schedules, each set by your prescriber.

Appetite suppression makes it easy to under-eat protein, and muscle is lost alongside fat when intake is too low during rapid weight loss. Build adequate protein and resistance training in from your first dose, not after you notice strength dropping — see protecting muscle on GLP-1 for specifics. During escalation weeks specifically, smaller portions, eating slowly, and easing off very rich or fried food help with the nausea that concentrates in the days after a step-up.